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November 21, 2009
         
DNA kit for uncovering ancestral history
Updated on Monday, July 09, 2007, 00:00 IST
Chennai, July 09: Want to know more about your roots? Buy a DNA analysis kit from the US-based National Geographic Society and know everything about your ancestors and their migratory history.

The public participation kit is made available by the society under its five-year genographic project, co-funded by software giant IBM and the Tedd Wait Family Foundation.

The project, which began in April 2005, primarily aims to collect and genotype at least 100,000 indigenous and traditional DNA samples from across the world to study the "journey of mankind".

However, it also allows people to volunteer samples which will help them learn about their own ancestral history, Ajay K Royyuru, a senior manager at IBM's Computational Biology Center, told reporters.

The kit can be ordered for 99 dollars via the internet. Cheek swab samples can be taken through a simple process and sent to the project's research laboratory. Over 210,000 people have so far purchased the kits, said Royyuru.

The cheek swab samples are processed at a research laboratory at the University of Arizona through "family tree DNA", a leading genetic genealogy company selected to perform the public participant testing for the project. the project has already analysed genetic data of 78,590 public participants from around the globe.

"This is the largest, quality-controlled, open-access DNA data bank for the world to use. Further, it has a new computer programme that allows classification of mitochondrial lineages with unprecedented accuracy," Royyuru said.

This programme -- nearest neighbour haplogroup prediction tool -- is now being made publicly available with the anonymous genetic data.

"These personal results will be stored securely and anonymously to ensure the privacy of participants. National Geographic Society and IBM will regularly update the public and the scientific community on these findings through websites," he said.

Individual participants will have an ID on the National Geographic Society website where information can be accessed.

The director of the project's Indian chapter, Ramasamy Pitchappan, said researchers have been exploring whether the analysis could be made cheaper and done in India for participants in the country.

"However, this is a policy to be made at the global level at all the 10 centres of the project across the globe and we need to wait for more Indians to participate in the project," he said.

Royyuru said: "Human DNA contains genetic markers that are passed down from generation to generation. These markers are small genetic mutations that can be traced to relatively specific times and places as humans migrated around the world. Looking at these markers, we draw conclusions about our migratory history."

Following them through generations reveals a genetic tree on which today's many diverse branches may be followed backward to their common African root.

Scientists are collecting this data from people across the globe, particularly indigenous populations, before modern globalisation further erodes cultural groupings that could provide the geographical and historical context for interpreting diverse genetic patterns, Royyuru said.

The net proceeds from the sale of the genographic project public participation kits would go to the Genographic Legacy Fund (GLF) that will be used to benefit indigenous people, those participating in the project and others.

"The GLF not only recognises the importance of these communities, but aims at empowering them," he said.

The fund will award micro and macro grants of up to USD 25,000 and USD 100,000 respectively to individuals and groups that demonstrate a passionate commitment to improving general awareness of indigenous and traditional cultures, histories and heritages.

IBM and National Geographic have also developed educational materials using the data available through the genographic project.

Bureau Report


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